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DEPO-PROVERA- medroxyprogesterone acetate injection ...

[3/7/2017 11:39:49 AM] depo - provera - medroxyprogesterone acetate injection , suspension Pharmacia and Upjohn Company LLC----------HIGHLIGHTS OF PRESCRIBING INFORMATIONT hese highlights do not include all the information needed to useDEPO- provera CI safely and effectively. See full prescribinginformation for depo - provera CI ( medroxyprogesterone acetate ) injectablesuspension, for intramuscular useInitial Approval: 1959 WARNING: LOSS OF bone mineral DENSITYSee full prescribing information for complete who use depo - provera Contraceptive injection ( depo - provera CI) may lose significant bone mineraldensity. bone loss is greater with increasing duration ofuse and may not be completely reversible. ( )It is unknown if use of depo - provera ContraceptiveInjection during adolescence or early adulthood, acritical period of bone accretion, will reduce peak bonemass and increase the risk for osteoporotic fracture inlater life.

14 CLINICAL STUDIES 14.1 Contraception 14.2 Bone Mineral Density (BMD) Changes in Adult Women 14.3 Bone Mineral Density Changes in Adolescent Females (12–18 years of age) 14.4 Relationship of fracture incidence to use of DMPA 150 mg IM or non-use by women of reproductive age 15 REFERENCES 16 HOW SUPPLIED/STORAGE AND HANDLING

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