Transcription of Dissolution Testing of Orally Disintegrating Tablets
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Dissolution Testing of Orally Disintegrating Tablets
6 DissolutionTechnologies| MAY 2003 IntroductionOrally Disintegrating Tablets contain a widevariety of pharmaceutical actives coveringmany therapeutic categories, and can beparticularly good applications for pediatric andgeriatric time for disintegration oforally Disintegrating Tablets is generally consideredto be less than one minute [1-4], although patientscan experience actual oral disintegration timesthat typically range from 5-30 seconds. Orally disin-tegrating Tablets are characterized by highporosity, low density, and low , an in-situ suspension is created inthe oral cavity as the tablet disintegrates and issubsequently swallowed. Recently, the Orally Disin-tegrating Tablets terminology has been approvedby the Nomenclature and Labeling committee atUSP (reference Nomeclature Notes, page 8).Although fast Disintegrating and patientpreferred, Orally Disintegrating Tablets are typi-cally not meant to have fastertherapeutic onset.
8 Dissolution Technologies | MAY 2003 Orally Disintegrating Tablets … continued development,a target specification can be set for taste-masked drug to assure acceptable/consistent taste.
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