Transcription of DNA 損傷チェックポイントとがん - jbsoc.or.jp
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DNA 損傷チェックポイントとがん - jbsoc.or.jp
Pp.. !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! !!! !!! . !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! DNA . Chk .. DNA ATM-Chk -p . ATR-Chk -Cdc . A . ATM-Chk - p . DNA . ATR-Chk -Cdc . A Chk .. Chk ATR . Chk . Chk .. DNA . DNA DNA .. DNA DNA . G S S CDK cyclin-dependent kinase . G M DNA . DNA . ATM ataxia-telangiectasia mutated . DNA . -Chk checkpoint kinase . -p .. DNA . ATM Chk p .. p . p .. p . CDK . DNA damage checkpoint and cancer pros and cons of Chk . inhibitors . Hidemasa Goto and Masaki Inagaki Division of Bio- G S . chemistry, Aichi Cancer Center Research Institute, . Kanokoden, Chikusa-ku, Nagoya, Aichi , Japan, .. Department of Cellular Oncology, Nagoya University Graduate School of Medicine, . Tsurumai-cho, Showa-ku, ATR ATM- and Nagoya, Aichi , Japan Rad -related; ATM Rad.
の結合を介して一本鎖dna 上にリクルートされてい る29，30）．つまり，atr によるchk1のセリン317およびセ リン345のリン酸化修飾は，dna 損傷部位近傍で引き起
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