Transcription of Dosage and administration - Medsafe
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Dosage and administration - Medsafe
Data Sheet New Zealand DBL cytarabine INJECTION. Presentation DBL cytarabine Injection 20 mg/mL, 50 mg/mL and 100 mg/mL is a clear colourless sterile solution of cytarabine BP in Water for Injections. Uses Actions cytarabine is an antineoplastic agent. cytarabine is a synthetic pyrimidine nucleoside, which is converted intracellularly to the nucleotide, cytarabine triphosphate. The exact mechanism of action of cytarabine is not fully understood, but cytarabine triphosphate appears to inhibit DNA synthesis by the inhibition of DNA polymerase. The enzyme responsible for this conversion is deoxycytidine kinase which is found predominantly in the liver and possibly the kidney. cytarabine is inactivated by the enzyme cytidine deaminase found in the intestine, kidney and liver.
Data Sheet –New Zealand Hosp 5.0 2 Immunosuppressive Action Cytarabine is capable of obliterating immune responses in man during administration with little or no
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