Transcription of Drug interactions involving warfarin: Practice tool …
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Drug interactions involving warfarin: Practice tool …
CPJ/RPC JANUARY/FEBRUARY 2011 VOL 144, NO 1 21 IntroductionWarfarin has been the mainstay of oral anticoagu-lant therapy for the past 60 years and it is most commonly used to treat or prevent thrombosis or thromboembolism in patients with venous throm-boembolism, atrial fibrillation and prosthetic heart However, this drug is efficacious only when the dosage is maintained within a narrow thera-peutic index, measured by the international nor-malized ratio (INR). Multiple challenges exist in appropriately achieving and maintaining therapy within this narrow index. Recent data have iden-tified genetic variants that may reduce a person s requirement for ,3 Furthermore, once a suitable dosage of warfarin has been established, control of therapy can be affected by changes in intake of vitamin K, development of acute medical conditions ( , fever, diarrhea), changes in certain chronic medical conditions ( , heart failure) and interactions with prescription, nonprescription and herbal numerous drug interactions involving war-farin are well known among health care providers.
CPJ/RPC • JANUARY/FEBRUARY 2011 • VOL 144, NO 1 21 Introduction Warfarin has been the mainstay of oral anticoagu-lant therapy for the past 60 years and it is most
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