Transcription of DRUG NAME: Paclitaxel - BC Cancer
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DRUG NAME: Paclitaxel - BC Cancer
Paclitaxel DRUG NAME: Paclitaxel SYNONYM(S): benzenepropanoic acid1 COMMON TRADE NAME(S): TAXOL , ONXOL CLASSIFICATION: antimicrotubule agent Special pediatric considerations are noted when applicable, otherwise adult provisions apply. MECHANISM OF ACTION: Paclitaxel is a taxane. Paclitaxel binds to tubulin, the protein component of microtubules, simultaneously promoting their assembly and disassembly to form stable, nonfunctional ,2 Although some reports indicate a cross-reactivity rate of 90% between docetaxel and Paclitaxel , others suggest it does not occur ,3 Stabilization of microtubules blocks cells in the M phase of the cell cycle, inhibiting cell division and causing cell Paclitaxel acts as a radiosensitizing agent by blocking cells in the Paclitaxel is an ,6 PHARMACOKINETICS: Oral Absorption no information found Distribution biphasic: initial distribution to peripheral compartment, then slow efflux from the peripheral compartment; widely distributed into body fluids and tissues1,7.
*Breast cancer Lung cancer, small cell: 2 *Lung cancer, non -small cell Esophageal cancer: 2 *Ovarian cancer Bladder cancer: 2 *Kaposi’s Sarcoma Head and Neck cancer: 2: Cervical cancer: 2: Endometrial cancer: 2 *Health Canada approved indication : SPECIAL PRECAUTIONS:
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