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Early Breast Cancer - European Society for Medical Oncology

Early Breast CancerESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upF. C a r d o s o , S . Kyriakides, S. Ohno, F. Penault-Llorca, P. Poortmans, I. T. Rubio, S. Zackrisson& E. Senkus, on behalf of the ESMO Guidelines Committee*For details of author affiliations, correspondence and versions, please seethe full version at 2019 ESMO. All rights reserved. of recommendationsRegular (annual or every 2 years) mammography in women aged 50 69 years and annual MRI of women with familial Breast Cancer are recommendedDiagnosis is based on clinical examination and imaging and confirmed by pathological assessmentBilateral mammogram and US of breasts and axillae are recommendedTumoursshould be grouped into surrogate intrinsic subtypes, defined by routine histology and IHC dataGenetic counselling and testing for germline BRCA1and BRCA2mutations should be offered to high-risk groupsScreening, Diagnosis, Pathology & Molecular biology 2019 ESMO.

•Physical examination •Full blood count •Liver, renal and cardiac (in patients planned for anthracycline and/or trastuzumab treatment) function tests, alkaline phosphatase and calcium Assessment of primary tumour •Physical examination •Mammography •Breast US •Breast MRI in …

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