Transcription of EASL Clinical Practice Guidelines: Autoimmune hepatitisq
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EASL Clinical Practice Guidelines: Autoimmune hepatitisq
EASL Clinical Practice Guidelines: Autoimmune hepatitisqEuropean Association for the Study of the Liver IntroductionAutoimmune hepatitis (AIH) was the first liver disease for whichan effective therapeutic intervention, corticosteroid treatment,was convincingly demonstrated in controlled Clinical , 50 years later AIH still remains a major diagnosticand therapeutic challenge. There are two major reasons for thisapparent contradiction: Firstly, AIH is a relatively rare , AIH is a very heterogeneous other rare diseases, Clinical studies are hampered by thelimited number of patients that can be included in trials. Possiblyand more importantly, the interest of the pharmaceutical indus-try to develop effective specific therapies for rare diseases is lim-ited due to the very restricted market for such products.
AIH prevalence and clinical expression seem to vary according to ethnicity. Alaskan natives appear to have a high frequency of acute icteric disease at the disease onset [12], and the disease is more common and more severe in North American Aboriginal/First Nations populations compared with predomi-nantly Caucasian, non-First Nations ...
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