Transcription of EASL Clinical Practice Guidelines: The diagnosis …
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EASL Clinical Practice Guidelines: The diagnosis …
EASL Clinical Practice guidelines : The diagnosis and managementof patients with primary biliary cholangitisqEuropean Association for the Study of the Liver SummaryPrimary biliary cholangitis (PBC) is a chronic inflammatoryautoimmune cholestatic liver disease, which when untreated willculminate in end-stage biliary cirrhosis. diagnosis is usuallybased on the presence of serum liver tests indicative of a chole-static hepatitis in association with circulating antimitochondrialantibodies. Patient presentation and course can be diverse andrisk stratification is important to ensure all patients receive a per-sonalised approach to their care. The goals of treatment and man-agement are the prevention of end-stage liver disease, and theamelioration of associated symptoms. Pharmacologic approachesin Practice , to reduce the impact of the progressive nature ofdisease, currently include licensed therapies (ursodeoxycholicacid and obeticholic acid) and off-label therapies (fibric acidderivatives, budesonide).
EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitisq European Association for the Study of the Liver⇑
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