Effect of relative humidity and temperature on …
International Journal of Pharmaceutics 166 (1998) 167 175 Effect of relative humidity and temperature on moisturesorption and stability of sodium bicarbonate powderWei-Youh Kuua,*, Rao Chilamkurtia, Chi ChenbaPharmaceutical Sciences R& Di6ision,Baxter Healthcare,Round Lake,IL60073,USAbRenal Di6ision,Baxter Healthcare,McGaw Park,IL60085,USAR eceived 7 April 1997; received in revised form 19 November 1997; accepted 9 January 1998 AbstractThe effects of relative humidity and temperature on moisture sorption rate and stability profile of sodiumbicarbonate powder exposed to various storage conditions were investigated using gravimetrical and acid-titrationmethods. In the study, samples were placed in desiccators, which contained various saturated salt solutions togenerate desired levels of relative humidity , denoted as RH, ranging from 30 93% RH. The weight of each samplewas determined periodically.
International Journal of Pharmaceutics 166 (1998) 167–175 Effect of relative humidity and temperature on moisture sorption and stability of sodium bicarbonate powder
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