Transcription of Effect of Superdisintegrants on Dissolution
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Effect of Superdisintegrants on Dissolution
Dissolution Technologies | MAY 200818e-mail: of Superdisintegrants on Dissolution of Cationic DrugsJ. Balasubramaniam1,4, K. Bindu1, V. U. Rao1, D. R ay2, R. Haldar2, and A. W. Brzeczko31 International Specialty Products (India) Pvt. Ltd., H. No 6-3-1090/A, Bhupal Towers, Rajbhavan Road, Somajiguda, Hyderabad 500 082, INDIA2 International Specialty Products, 1361 Alps Road, Wayne, NJ 074703 ISP Pharma Systems LLC, 9176 Red Branch Road, Columbia, MD 21045 ABSTRACTThe effects of selected Superdisintegrants on the Dissolution behavior of several cationic drugs with varying water solubility were evaluated.
20 Dissolution Technologies | MAY 2008 Table 2. Hardness and Disintegration Time (DT) for the Prepared Tablets. Drug Superdisintegrant Hardness (N) DT (min) Ciprofloxacin Croscarmellose sodium 182 ± 4 4.5 ± 0.3 SSG 187 ± 6 3.5 ± 0.3
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