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Effects of Nonsteroidal Antiinflammatory Drugs on …

THERAPEUTIC REVIEW. Effects of Nonsteroidal Antiinflammatory Drugs on platelet Function and Systemic Hemostasis Andrew I. Schafer, MD. Aspirin and nonaspirin Nonsteroidal Antiinflammatory Drugs (NSAIDsJ inhibit platelet cyclooxygenase, thereby blocking the formation of thromboxane A2 These Drugs produce a systemic bleeding tendency by impairing thromboxane-dependent platelet aggregation and consequently prolonging the bleeding time. Aspirin exerts these Effects by irrevers . ibly blocking cyclooxygenase and, therefore, its actions persist for the circulating lifetime of the platelet .)

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