Transcription of Empiric Therapy of Cardiovascular Infections Subacute ...
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Chapter 2. Empiric Therapy : Cardiovascular Infections51 Empiric Therapy of Cardiovascular InfectionsSubacute bacterial endocarditis (SBE)SubsetUsualPathogensPreferred IVTherapyAlternate IVTherapyPO Therapy or IV-to-PO SwitchNo obvioussourceS. viridansGroup B,C,G streptococciNutritionally-variant streptococciCeftriaxone 2 gm (IV) q24hx 2 weeksplusGentamicin 120 mg (IV) q24h x 2 weeksor monotherapywithCeftriaxone2 gm (IV) q24hx 2 weeksPenicillin G 3 mu (IV) q4hx 2 weeksplusGentamicin180 mg (IV) q24hx 2 weeksor monotherapywithVancomycin1 gm (IV) q12hx 2 weeksorLinezolid600 mg (IV) q12hx 2 weeksAmoxicillin1 gm (PO) q8hx 2 weeksorLinezolid600 mg (PO) q12hx 2 weeksGI/GUsource likely(Treat initiallyfor E. faecalis;if lateridentified as , treataccordingly)E. faecalis Vancomycin1 gm (IV) q12hx 4-6 weeksplusGentamicin80 mg (IV) q8hx 4-6 weeksor monotherapywith Ampicillin 2 gm (IV) q4hx 4-6 weeksMeropenem1 gm (IV) q8hx 4-6 weeksorImipenem1 gm (IV) q6hx 4-6 weeksorLinezolid600 mg (IV) q12hx 4-6 weeksAmoxicillin1 gm (PO) q8hx 4-6 weeksorLinezolid600 mg (PO) q12hx 4-6 weeks E.
Chapter 2. Empiric Therapy: Cardiovascular Infections 51 Empiric Therapy of Cardiovascular Infections Subacute Bacterial Endocarditis (SBE) Subset
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