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ENDOCRINE TEST PROTOCOLS

July 24, 2018 Page 1 of 24 MEDICAL INVESTIGATION FACILITY ENDOCRINOLOGY & DIABETES UNIT ENDOCRINE TEST PROTOCOLS July 24, 2018 Page 2 of 24 ACTH STIMULATION TEST ..3 COSYNTROPIN 1 g/mL INJECTION ..4 oCRH STIMULATION TEST ..5 GROWTH HORMONE STIMULATION TESTS ..6 ARGININE ..6 GLUCAGON ..7 CLONIDINE ..7 INSULIN ..8 TRH STIMULATION TEST ..9 GnRH STIMULATION TEST .. 10 GLUCOSE TOLERANCE TEST FOR DIABETES ORAL .. 11 GLUCOSE TOLERANCE TEST IV .. 12 PROLONGED FAST FOR EVALUATION OF HYPOGLYCEMIA .. 13 GLUCAGON STIMULATION TEST FOR HYPOGLYCEMIA .. 15 GROWTH HORMONE SUPPRESSION TEST .. 16 CALCIUM PENTAGASTRIN STIMULATION TEST .. 17 WATER DEPRIVATION TEST .. 19 HYPERTONIC SALINE INFUSION TEST .. 20 APPENDICES .. 21 July 24, 2018 Page 3 of 24 ACTH STIMULATION TEST PURPOSE: The rapid ACTH stimulation test measures the adrenal response to ACTH and is used to diagnose primary and secondary adrenal insufficiency and defects of adrenal hormone synthesis.

SIDE-EFFECTS: Drowsiness is common following clonidine and many patients fall asleep. Blood pressure changes are usually found, with systolic blood pressure decreased 10–25 mm Hg and diastolic blood pressure decreased 5–15 mm Hg without symptoms.

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