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ENDOCRINE TEST PROTOCOLS - BC Children’s

July 24, 2018 Page 1 of 24 MEDICAL INVESTIGATION FACILITY ENDOCRINOLOGY & DIABETES UNIT ENDOCRINE TEST PROTOCOLS July 24, 2018 Page 2 of 24 ACTH STIMULATION TEST ..3 COSYNTROPIN 1 g/mL INJECTION ..4 oCRH STIMULATION TEST ..5 GROWTH HORMONE STIMULATION TESTS ..6 ARGININE ..6 GLUCAGON ..7 CLONIDINE ..7 INSULIN ..8 TRH STIMULATION TEST ..9 GnRH STIMULATION TEST .. 10 GLUCOSE TOLERANCE TEST FOR DIABETES ORAL .. 11 GLUCOSE TOLERANCE TEST IV .. 12 PROLONGED FAST FOR EVALUATION OF HYPOGLYCEMIA .. 13 GLUCAGON STIMULATION TEST FOR HYPOGLYCEMIA .. 15 GROWTH HORMONE SUPPRESSION TEST .. 16 CALCIUM PENTAGASTRIN STIMULATION TEST .. 17 WATER DEPRIVATION TEST .. 19 HYPERTONIC SALINE INFUSION TEST .. 20 APPENDICES .. 21 July 24, 2018 Page 3 of 24 ACTH STIMULATION TEST PURPOSE: The rapid ACTH stimulation test measures the adrenal response to ACTH and is used to diagnose primary and secondary adrenal insufficiency and defects of adrenal hormone synthesis.

with bone age >9 years up until Tanner 4 pubertal stage will be primed with micronized 17β-estradiol (Estrace®, 2 mg/day for body weight ≥20 kg, 1 mg/day for body weight <20 kg) for the two nights prior to testing. The physician will decide which tests will be performed. Only pharmacologic tests are currently used routinely.

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