Transcription of Experimental design and sample size determination
{{id}} {{{paragraph}}}
1 Experimental designand sample size determinationKarl W BromanDepartment of BiostatisticsJohns Hopkins ~kbromanNote This is a shortened version of a lecture which is part of a web-based course on Enhancing Humane Science/ImprovingAnimal Research (organized by Alan Goldberg, Johns HopkinsCenter for Alternatives to Animal Testing) Few details mostly design3 Basic question/goal in (aka blocking) experiments43 ExampleQuestion:Does salted drinking water affect blood pressure (BP) in mice? a mouse with water containing 1% 14 experiments are comparative.
Sample size determination 24. 13 Fundamental formula $ per sample $ available n= 25 Listen to the IACUC Too few animals → a total waste Too many animals → a partial waste 26. 14 Significance test • Compare the BP of 6 mice fed salt water to …
Domain:
Source:
Link to this page:
Please notify us if you found a problem with this document:
{{id}} {{{paragraph}}}