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Fever in the ICU*

Fever in the ICU*Paul E. Marik, MD, FCCPF ever is a common problem in ICU patients. The presence of Fever frequently results in theperformance of diagnostic tests and procedures that significantly increase medical costs andexpose the patient to unnecessary invasive diagnostic procedures and the inappropriate use ofantibiotics. ICU patients frequently have multiple infectious and noninfectious causes of Fever ,necessitating a systematic and comprehensive diagnostic approach. Pneumonia, sinusitis, andblood stream infection are the most common infectious causes of Fever . The urinary tract isunimportant in most ICU patients as a primary source of infection. Fever is a basic evolutionaryresponse to infection, is an important host defense mechanism and, in the majority of patients,does not require treatment in itself.

IL-6, and TNF-a will result in the development of fever. While infections are the commonest cause of fever in ICU patients, many noninfectious inflamma-

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