Transcription of Flow-Through Cell Apparatus (USP ... - Dissolution Tech
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Flow-Through Cell Apparatus (USP ... - Dissolution Tech
Flow-Through Cell Apparatus (USP. Apparatus 4): Operation and Features Nikoletta Fotaki e-mail: Department of Pharmacy & Pharmacology, University of Bath, Claverton Down, BA2 7AY, Bath, UK. INTRODUCTION into the inlet tubing. Different amounts of small glass D. issolution testing plays an important role in several beads can be used according to the experimental setup. areas during drug development. It can be used as a The sample can be placed upon a holder but also can be quality control tool to monitor batch-to-batch placed on or within the glass-bead bed. For dispersed consistency of drug release from a dosage form and as an systems ( , suspensions, powders), mixing of the sample in vitro surrogate for in vivo performance that can guide within the glass-bead bed has also been reported.
flow-through cell system with other systems, for enhancing knowledge of dissolution and performance of dosage forms. For example, integration of the flow-through cell apparatus with MRI system has been proposed for discriminative evaluation of controlled-release dosage forms with similar dissolution profiles by investigating
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