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Gilead Sciences 1 HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use BIKTARVY safely and effectively. See full prescribing information for BIKTARVY . BIKTARVY (bictegravir, emtricitabine, and tenofovir alafenamide) tablets, for oral use Initial Approval: 2018 WARNING: POST TREATMENT acute EXACERBATION OF HEPATITIS B See full prescribing information for complete boxed warning. Severe acute exacerbations of hepatitis B have been reported in patients who are coinfected with HIV-1 and HBV and have discontinued products containing emtricitabine (FTC) and/or tenofovir disoproxil fumarate (TDF), and may occur with discontinuation of BIKTARVY .

See full prescribing information for complete boxed warning. • Severe acute exacerbations of hepatitis B have been reported in patients who are coinfected with HIV -1 and

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