Transcription of FOR INTRAVENOUS USE ONLY
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NDA 50-706/S-022 Page 3 MERREM (meropenem for injection) FOR INTRAVENOUS USE ONLY To reduce the development of drug-resistant bacteria and maintain the effectiveness of MERREM (meropenem for injection) and other antibacterial drugs, MERREM should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. DESCRIPTION MERREM (meropenem for injection) is a sterile, pyrogen-free, synthetic, broad-spectrum, carbapenem antibiotic for INTRAVENOUS administration.
and Pseudomonas aeruginosa; and PBPs 1, 2 and 4 of Staphylococcus aureus. Bactericidal concentrations (defined as a 3 log10 reduction in cell counts within 12 to 24 hours) are typically 1-2 times the bacteriostatic concentrations of meropenem, with the exception of Listeria monocytogenes, against which lethal activity is not observed.
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