Functional Gastrointestinal Disorders - Rome Foundation

SECTION I: FGIDs: BACKGROUND INFORMATIONF unctional Gastrointestinal Disorders : History, Pathophysiology,Clinical Features, and Rome IVDouglas A. DrossmanCenter for Education and Practice of Biopsychosocial Care, Drossman Gastroenterology; Center of Functional GI and MotilityDisorders, University of North Carolina; and Rome Foundation , Chapel Hill, North CarolinaFunctional Gastrointestinal Disorders (FGIDs), the mostcommon diagnoses in gastroenterology, are recognized bymorphologic and physiological abnormalities that oftenoccur in combination including motility disturbance,visceral hypersensitivity, altered mucosal and immunefunction, altered gut microbiota, and altered central ner-vous system processing. Research on these gut braininteraction Disorders is based on using specific diagnosticcriteria. The Rome Foundation has played a pivotal role increating diagnostic criteria, thus operationalizing thedissemination of new knowledge in thefield of IV is a compendium of the knowledge accumulatedsince Rome III was published 10 years ago.

knowledge of gastrointestinal symptoms and illness, consequently leading to the identification and categorization of functional gastrointestinal (GI) disorders. Antiquity Through the Late 19th Century: Holism and Cartesian Dualism The possibility that passions or emotions could lead to the development of medical disease was first proposed by

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