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Functional magnetic resonance imaging based on …

Functional magnetic resonance imaging based onChanges in Vascular Space OccupancyHanzhang Lu,1 3*Xavier Golay,1,3 James J. Pekar,1,3and Peter van Zijl1,3*During brain activation, local control of oxygen delivery is facil-itated through microvascular dilatation and constriction. A newfunctional MRI (fMRI) methodology is reported that is sensitiveto these microvascular adjustments. This contrast is accom-plished by eliminating the blood signal in a manner that isindependent of blood oxygenation and flow. As a consequence,changes in cerebral blood volume (CBV) can be assessedthrough changes in the remaining extravascular water signal( , that of parenchymal tissue) without need for exogenouscontrast agents or any other invasive procedures.

Functional Magnetic Resonance Imaging Based on Changes in Vascular Space Occupancy Hanzhang Lu,1–3* Xavier Golay, 1,3James J. Pekar,1,3 and Peter C.M. van Zijl * During brain activation, local control of oxygen delivery is facil-

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