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Generalized Linear Mixed Models - Fall 2012

Generalized Linear Mixed Multilevel Models ), in which the level-1 observa- tions (subjects or repeated observations) are nested Models within the higher level-2 observations (clusters or subjects). Higher levels are also possible, for exam- ple, a three-level design could have repeated obser- Introduction vations (level-1) nested within subjects (level-2) who are nested within clusters (level-3). Generalized Linear Models (GLMs) represent a class For analysis of such multilevel data, random of fixed effects regression Models for several types of cluster and/or subject effects can be added into the dependent variables ( , continuous, dichotomous, regression model to account for the correlation of counts).

Generalized Linear Mixed Models 3 Table 1 Smoking cessationstudy:smokingstatus (0 = smoking, 1 = not smoking)acrosstime(N = 489),GLMM logistic parameter estimates (Est.), standard errors (SE), and P values Random intercept model Random int and trend model Parameter Est. SE P value Est. SE P value Intercept −2.867 .362 .001 −2.807 .432 .001

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