Glycolysis The Glycolytic Pathway The Reactions of ...

GlycolysisThe Glycolytic PathwayThe Reactions of GlycolysisFermentation: The Anaerobic Fate of PyruvateControl of Metabolic FluxMetabolism of Hexoses Other Than GlucoseThe Glycolytic Pathway (Embden-Meyerhof-Parnas Pathway ) Glycolysis converts one C6 unit (glucose) to two C3 units(pyruvate) of lower energy in a process that harnesses thereleased free energy to synthesize ATP from ADP and PiOverall reaction -Glucose + 2 NAD+ + 2 ATP + 2Pi 2 NADH + 2pyruvate + 2 ATP + 2H2O + 4H+Stage I - Investment of 2 ATP to split hexose glucose into 2molecules of triose glyceraldehyde-3-phosphateStage II - Generation of 4 ATP from the conversion ofglyceraldehyde-3-phosphate into pyruvateGlycolytic enzymes located in cytosol, loosely associated,no organized complexesOxidizing power of NAD+ must be muscle - homolactic yeast - alcohol conditions - mitochondrial oxidationReactions of GlycolysisHexokinase (glucokinase in liver)phosphoryl group transfer - first ATP investmentRandom Bi Bi mechanismternary complex with glucose-Mg2+-ATP ( catalysis byproximity effects)

(pyruvate) of lower energy in a process that harnesses the ... (catalysis by proximity effects) Reactions of Glycolysis Phosphoglucose isomerase (glucose-6-phosphate ... [AMP] Consider substrate cycling: Two enzymes are involved in establishing equilibrium-like conditions: 1. Phosphofructokinase-1 (PFK-1)

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  Pathway, Energy, Catalysis, Glycolytic pathway, Glycolytic

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