Guide to the Homogenization of Biological Samples

Random Primers, Issue No. 7, Sept. 2008, Page 1-14 Guide to the Homogenization of Biological Samples A 2012 update of this Guide can be found by clicking this link. David W. Burden, Abstract Many tools are available for the Homogenization of Samples . These homogenizers can be generally grouped into those that grind, shear, beat, and shock, though many disruption processes rely on more than one type of force. When developing a disruption scheme, it is critical to define the characteristics of the homogenate and then select the tools that will help to meet the objectives. The examination of methods used to homogenize Samples has shown that effectiveness is directly related to the nature of the sample.

Sample disruption, or homogenization, is not the most exciting methodology to examine, but none-the-less it does have significant impact on the end results of a process. Though used daily and extensively, methods for sample disruption are not necessarily well understood. Indeed like many well established lab processes, the

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