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Guidelines for Assessing the Health and Condition of Mice

Transgenic and knockout technologieshave caused a shift in research focus atmany institutions. Increased numbers ofmice some with potentially debilitatingphenotypes are being maintained totheir natural life spans, and this has chal-lenged the laboratory animal communityto devise effective strategies for monitoringand managing these from meeting essential obliga-tions for ensuring the well-being (freedomfrom discomfort, distress, and pain) of theresearch mouse, effective management andsupervision of mouse colonies is useful infulfilling the 3 Rs (replacement, reduc-tion, refinement) put forth by Russell andBurch1.

and Care of Vertebrate Animals Used in Testing, Research, and Training, investiga-tors have an obligation to minimize pain, discomfort, and distress in the animals used in their research. Part of fulfilling that obligation is recognizing when an animal’s well-being is compromised. We recommend evaluating individual

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