Transcription of Guidelines for Carcinogen Risk Assessment
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Guidelines for Carcinogen Risk Assessment
EPA/630/P-03/001 BMarch 2005 Guidelines for Carcinogen Risk Assessment Risk Assessment Forum Environmental Protection Agency Washington, DC DISCLAIMER Mention of trade names or commercial products does not constitute endorsement or recommendation for use. CONTENTS 1. INTRODUCTION .. 1-1 PURPOSE AND SCOPE OF THE Guidelines .. 1-1 ORGANIZATION AND APPLICATION OF THE Guidelines .. 1-3 Organization .. 1-3 Application .. 1-5 KEY FEATURES OF THE CANCER Guidelines .. 1-7 Critical Analysis of Available Information as the Starting Point for Evaluation .. 1-7 Mode of Action .. 1-10 Weight of Evidence Narrative .. 1-11 Dose-response Assessment .. 1-12 Susceptible Populations and Lifestages.
innovations and contemporaneous scientific concepts. In balancing these goals, the Agency relies on established scientific peer review processes (U.S. EPA, 2000a; OMB 2004). The cancer guidelines incorporate basic principles and science policies based on evaluation of the currently available information.
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