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Guidelines for Diagnosis, Treatment, and …

478 PRACTICE Guidelines nature publishing group CME. Guidelines for diagnosis , treatment , and Prevention of Clostridium difficile Infections Christina M. Surawicz, MD1, Lawrence J. Brandt, MD2, David G. Binion, MD3, Ashwin N. Ananthakrishnan, MD, MPH4, Scott R. Curry, MD5, Peter H. Gilligan, PhD6, Lynne V. McFarland, PhD7,8, Mark Mellow, MD9 and Brian S. Zuckerbraun, MD10. Clostridium difficile infection (CDI) is a leading cause of hospital-associated gastrointestinal illness and places a high burden on our health-care system. Patients with CDI typically have extended lengths-of-stay in hospitals, and CDI is a frequent cause of large hospital outbreaks of disease.

478 nature publishing group The American Journal of GASTROENTEROLOGY VOLUME 108 | APRIL 2013 www.amjgastro.com PRACTICE GUIDELINES INTRODUCTION Clostridium diffi cile inf ection (CDI) is a leading cause of hospital-

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