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Guidelines for the Design and Statistical Analysis of ...

Guidelines for the Design and Statistical Analysis of ExperimentsUsing Laboratory AnimalsMichael F. W. Festing and Douglas G. AltmanAbstractFor ethical and economic reasons, it is important to designanimal experiments well, to analyze the data correctly, andto use the minimum number of animals necessary to achievethe scientific objectives but not so few as to miss biologi-cally important effects or require unnecessary repetition ofexperiments. Investigators are urged to consult a statisticianat the Design stage and are reminded that no experimentshould ever be started without a clear idea of how the re-sulting data are to be analyzed.

Guidelines for the Design and Statistical Analysis of Experiments Using Laboratory Animals Michael F. W. Festing and Douglas G. Altman Abstract For ethical and economic reasons, it is important to design

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