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Guidelines for the diagnosis and antibiotic treatment of ...

Guidelines for the diagnosis and antibiotic treatment of endocarditisin adults: a report of the Working Party of the British Societyfor Antimicrobial ChemotherapyF. Kate Gould1*, David W. Denning2, Tom S. J. Elliott3, Juliet Foweraker4, John D. Perry1, Bernard D. Prendergast5,Jonathan A. T. Sandoe6, Michael J. Spry1and Richard W. Watkin71 Department of Microbiology, Freeman Hospital, Newcastle upon Tyne, UK;2 National Aspergillosis Centre, University Hospital of SouthManchester, Manchester, UK;3 Department of Microbiology, Queen Elizabeth Hospital, Birmingham, UK;4 Department of Microbiology,Papworth Hospital, Cambridge, UK;5 Department of Cardiology, John Radcliffe Hospital, Oxford, UK;6 Department of Microbiology, LeedsTeaching Hospitals NHS Trust, Leeds, UK;7 Department of Cardiology, Heart of England NHS Foundation Trust, Birmingham, UK*Corresponding author. Tel:+44-191-223-1248; Fax:+44-191-223-1224; E-mail: BSAC Guidelines on treatment of infectious endocarditis (IE) were last published in 2004.

infection is established and/or the need for surgery.9 Sometimes multiple scans are needed to demonstrate vegetations. Echocardiographic findings are major criteria in the diagnosis of IE, and may include the presence of a vegetation, abscess, new dehiscence of a prosthetic valve and newly noted valvular regurgitation.

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