GUIDELINES Post-Exposure Prophylaxis

8*/5&3 5)& 4065)&3/ "'3*$"/ +063/"- 0' )*7 .&%*$*/& KEY SUMMARY POINTSn Southern Africa differs from other regions, particularly in terms of very high HIV and hepatitis B Post-Exposure Prophylaxis (PEP) GUIDELINES lack a substantive evidence base to guide advice. It is extremely unlikely that this will change, as randomised studies of different drug regimens for PEP are not feasible owing to the complexity of exposure , low event rate, and inability to ethically have a placebo group. Evolving basic science understanding, along with further studies on animals and prevention of mother-to-child transmission (PMTCT) findings, will continue to guide policy Prior PEP GUIDELINES are not user friendly, and rarely acknowledge the complex range of situations that occur with Selecting patients for appropriate PEP administration must be simplified.

5)& 4065)&3/ "'3*$"/ +063/"- 0' )*7 .&%*$*/& 8*/5&3 Clinical approach n Animal data, case control studies and PMTCT data

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  Post, Exposure, Post exposure

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