Heart Failure with a Preserved Ejection Fraction: …

INTRODUCTIONMore than thirty years ago, it was recognised that signs and symptoms of Heart Failure may occur in patients in whom the Ejection fraction of the left ventricle (LV) is within normal limits. Although origi-nally studied in patients with genuine hypertrophic cardiomyopathy, Heart Failure with Preserved LV Ejection fraction (HFPEF) has now been recognised in a more common population, which is character-ised by a high prevalence of female gender, arterial hypertension, advanced age, obesity and diabetes mellitus. Interestingly, community surveys on chronic Heart Failure in general have shown that the overall dis-tribution of left ventricular Ejection fraction (LVEF) among patients with Heart Failure is bell-shaped1 and that the fraction of patients with a Preserved LVEF within this distribution is much larger than anticipated, currently being about 50% of patients2.

What if a clinical trial would indicate that heart failure patients with a normal maximal oxygen consumption (VO2 max) would show less benefit to aldosteron inhibitors as compared to patients with

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  With, Failure, Fractions, Ejection, Preserved, Failure with a preserved ejection fraction

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