Hematologic Changes in Sepsis and Their …

Hematologic Changes in Sepsis and TheirTherapeutic ImplicationsRichert E. Goyette, ,1 Nigel S. Key, ,2and E. Wesley Ely, , blood and bone marrow constitute the Hematologic organ system. Unlikeother organ systems, Hematologic organs are distributed in space and provide for a varietyof seemingly unrelated functions. The Hematologic system has both cellular and fluid-phaseelements. Cellular elements include erythrocytes, leukocytes, and platelets; fluid phaseelements include coagulation factors, natural antithrombotics, and proteins of the fibri-nolytic system. The most common abnormalities of the Hematologic system in patientswith Sepsis are anemia, leukocytosis, thrombocytopenia, and activation of the hemostaticsystem. Dysfunction of the Hematologic organ system is an early manifestation of severesepsis and is seen in virtually all patients with this disease. In concert with alterations in theendothelium, Hematologic Changes reflect both the body s reaction to an infectious insult aswell as attempts to restore homeostasis.

Hematologic Changes in Sepsis and Their Therapeutic Implications Richert E. Goyette, M.D.,1 Nigel S. Key, M.D.,2 and E. Wesley Ely, M.D., M.P.H.3 ABSTRACT The blood and bone marrow constitute the hematologic organ system.

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  Implications, Change, Their, Therapeutic, Sepsis, Hematologic, Hematologic changes in sepsis and, Hematologic changes in sepsis and their therapeutic implications

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