Transcription of Hemolytic Anemia: Evaluation and Differential Diagnosis
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Hemolytic Anemia: Evaluation and Differential Diagnosis
354 American Family Physician Volume 98, Number 6 September 15, 2018 Hemolytic anemia is defined as the destruction of red blood cells (RBCs) before their normal 120-day life span. It includes many separate and diverse entities whose common clinical features can aid in the identification of hemolysis. Hemolytic anemia exists on a spectrum from chronic to life-threatening, and warrants consideration in all patients with unexplained normocytic or macrocytic destruction of RBCs can occur intravascu-larly or extravascularly in the reticuloendothelial sys-tem, although the latter is more common. The primary extravascular mechanism is sequestration and phago-cytosis due to poor RBC deformability ( , the inabil-ity to change shape enough to pass through the spleen). Antibody-mediated hemolysis results in phagocytosis or complement-mediated destruction, and can occur intra-vascularly or extravascularly.
Sep 15, 2018 · Hemolytic anemia is defined as the destruction of red ... lytic disease of the fetus and newborn Trapping, phagocytosis, ... ec C = consensus, disease-oriented evidence, usual …
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