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HIGHLIGHTS •OF PRESCRIBING INFORMATION …

HIGHLIGHTS OF PRESCRIBING INFORMATION Neuropsychiatric Adverse Events During Smoking Cessation: These HIGHLIGHTS do not include all the INFORMATION needed to use Postmarketing reports of serious or clinically significant CONTRAVE safely and effectively. See full PRESCRIBING neuropsychiatric adverse events have included changes in mood INFORMATION for CONTRAVE. (including depression and mania), psychosis, hallucinations, paranoia, delusions, homicidal ideation, aggression, hostility, CONTRAVE (naltrexone HCl and bupropion HCl) Extended- agitation, anxiety, and panic, as well as suicidal ideation, suicide Release Tablets attempt, and completed suicide.

WARNING: SUICIDAL THOUGHTS AND BEHAVIORS SUICIDALITY AND ANTIDEPRESSANT DRUGS CONTRAVE® is not approved for use in the treatment of major depressive disorder or other psychiatric disorders. CONTRAVE contains bupropion, the same active ingredient

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