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HIGHLIGHTS OF PRESCRIBING INFORMATION • Efficacy …

1 HIGHLIGHTS OF PRESCRIBING INFORMATIONT hese HIGHLIGHTS do not include all the INFORMATION needed to use ZYPREXA safely and effectively. See full PRESCRIBING INFORMATION for (olanzapine) Tablet for Oral useZYPREXA ZYDIS (olanzapine) Tablet, Orally Disintegrating for Oral useZYPREXA IntraMuscular (olanzapine) Injection, Powder, For Solution for Intramuscular useInitial Approval: 1996 WARNING: INCREASED MORTALITYIN ELDERLY PATIENTSWITH DEMENTIA-RELATED PSYCHOSISSee full PRESCRIBING INFORMATION for complete boxed warning. Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.

Treatment Resistant Depression in adults(2.6) Oral in combination with fluoxetine: Start at 5mg of oral olanzapine and 20mg of fluoxetine once daily • Lower starting dose recommended in debilitated or pharmacodynamically sensitive patients or patients with predisposition to hypotensive reactions, or with potential for slowed metabolism.(2.1)

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