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HIGHLIGHTSOF PRESCRIBINGINFORMATION Hyperglycemia …

HIGHLIGHTS OF PRESCRIBING INFORMATIONT hese highlights do not include all the information needed to use TOUJEO safely andeffectively. See full prescribing information for TOUJEO .TOUJEO (insulin glargine injection) U-300, for subcutaneous useInitial Approval: 2015 RECENT MAJOR CHANGES Dosage and Administration ( , )3/2018 Warnings and Precautions ( , )3/2018 INDICATIONS AND USAGE TOUJEO is a long-acting human insulin analog indicated to improve glycemic control in adults withdiabetes mellitus. (1)Limitations of Use:Not recommended for treating diabetic ketoacidosis. (1) DOSAGE AND ADMINISTRATION Individualize dose based on type of diabetes, metabolic needs, blood glucose monitoringresults and glycemic control goal. ( , , ) Administer subcutaneously once daily at any time during the day, at the same time every day.( ) Rotate injection sites to reduce the risk of lipodystrophy.

Hyperglycemia or hypoglycemia with changes in insulin regimen: Make changes to a patient’s insulin regimen (e.g., insulin strength, manufacturer, type, injection site, or method of administration) under close medical supervision with increased frequency of blood glucose monitoring. (5.2) • Hypoglycemia: May be life-threatening.

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