Transcription of Hit discovery and hit-to-lead approaches
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Drug discovery Today Volume 11, Numbers 15/16 August 2006 REVIEWS. Reviews POST SCREEN. Hit discovery and hit-to-lead approaches Gyo rgy M. Keseru 1 and Gergely M. Makara2. 1. CADD&HTS Unit, Gedeon Richter Ltd, 19-21 Gyo mro i u t, Budapest, H-1103, Hungary 2. Merck Research Laboratories, Merck & Co, RY80Y-325, 126 E. Lincoln Ave, Rahway, New Jersey, 07065, USA. Hit discovery technologies range from traditional high-throughput screening to affinity selection of large libraries, fragment-based techniques and computer-aided de novo design, many of which have been extensively reviewed. Development of quality leads using hit confirmation and hit-to-lead approaches present their own challenges, depending on the hit discovery method used to identify the initial hits. In this paper, we summarize common industry practices adopted to tackle hit-to-lead challenges and review how the advantages and drawbacks of different hit discovery techniques could affect the various issues hit-to-lead groups face.
Drug Discovery Today Volume 11,Numbers 15/16 August 2006 REVIEWS Hit discovery and hit-to-lead approaches Gyo¨rgy M. Keseru˝1 and Gergely M. Makara2 1CADD&HTS Unit, Gedeon Richter Ltd, 19-21 Gyo¨mro˝iu´t, Budapest, H-1103, Hungary
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The discovery process, The Art Of Self Discovery, The art of self- discovery, Chapter 6 The Civil Litigation Process, BUSINESS PROCESS OPTIMIZATION IN THE CONTACT, Motion to Compel Discovery Responses, Discovery Service AWS, Discovery Service, Discovery Service? AWS, DISCOVERY, The Discovery, RULES OF CIVIL PROCEDURE, Supreme Court of Ohio