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I Introduction II G Protein-coupled Receptors III Receptor ...

MCB110-Spring 2008-NogalesSignaling 15 CELL SIGNALINGI IntroductionA. Types of SignalingB. Types of ReceptorsC. Other Conserved FunctionsII G Protein-coupled ReceptorsA. Heterotrimeric G proteinsB. G-protein coupled receptorsC. Second messenger cAMP: Glucose mobilizationD. Lipid-derived Second MessengersE. Calcium SignalingIII Receptor Tyrosine KinasesA. Insulin ReceptorB. General RTKs, Ras and the MAP kinase cascadeIV Integrin SignalingV Cell Signaling and ApoptosisVI Relationships between Signaling PathwaysSuggested Reading: Lodish, Chapter 13; Chapter 14, to , Chapter 15 MCB110-Spring 2008-NogalesSignaling 2 Essential to the survival of every cell is tomonitor the environment and to respond toexternal stimuli. For most cells this includesappropriate communication with neighboringcells.

• The enzyme phosphorylase catalyzes glycogen breakdown, while glycogen synthase catalyzes polymerization. • Regulation is achieved by several hormones, such as glucagon (from the pancreas) and epinephrine (from the adrenal medulla). Binding of epinephrine or glucagon to their receptors activates adenyl cyclase. cAMP binds to the regulatory ...

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