Transcription of I. Pulmonary Toxicology The Nanotoxicology Research ...
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I. Pulmonary Toxicology The Nanotoxicology Research ...
1 The Nanotoxicology Research Program in NIOSHV incent Castranova, PhDNIOSH Nanotoxicology Research Toxicology (8 projects) Effects(3 projects)III. Dermal Effects(1 project)IV. Predictive Algorithms(2 projects) Toxicity - IssuesA. Deposition pattern, interstitialization, clearanceB. Pulmonary reactionsC. Relevance of intratracheal instillation or aspiration to inhalation exposureD. Genotoxicity, carcinogenicityE. Relevance of exposure doses in animal models to occupational Toxicity - Projects1. Pulmonary toxicity of carbon nanotubeparticles Dr. Shvedova, PIa) Raw SWCNT (30% iron by weight) generate ROS with bronchial epithelial cells in vitro(Shvedova et al, 2004).b) Purified SWCNT (acid treated) generate low ROS and are less cytotoxic (Kagan et al, 2006).c) Aspiration of purified SWCNT in a mouse model (Shvedova et al, 2005):1) Rapid but transient inflammation and damage2) Agglomerates deposit at the terminal bronchioles and proximal alveoli; cause ) More dispersed structures cause rapid and progressive interstitial Toxicity Projects1.
1 The Nanotoxicology Research Program in NIOSH Vincent Castranova, PhD NIOSH Nanotoxicology Research Program I. Pulmonary Toxicology (8 projects) II.
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