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Importance, Objectives & Factors Affecting Dissolution ...

Importance, Objectives & Factors Affecting Dissolution Rate, Theories of Dissolution And Official Dissolution Tests (Equipments of Dissolution Study) LIST OF CONTENTS Introduction Importance & applications Factor Affecting Dissolution rate 1. Physicochemical Properties of Drug 2. Drug Product Formulation Factors 3. Processing Factors 4. Factors Relating Dissolution Apparatus 5. Factors Relating Dissolution Test Parameters Theories of Dissolution 1. Diffusion layer model (Film theory) 2. Danckwert s model (Penetration or Surface Renewal theory) 3.

interfacial tension, increasing effective surface area, which in turn results in faster dissolution rate. E.g Non-ionic surfactant Polysorbate 80 increase dissolution rate of phenacetin granules. The increase was more pronounced when the surfactant was sprayed on

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