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IN-SERVICE PRESENTATION

IN-SERVICE PRESENTATION IC-215308-AG OCT2015 1 of 84 This material is not for use in the , France or Japan. What have we achieved together? E v o l u t i o n o f S t e n t D e s i g n A D VA N C I N G C A R D I O L O G Y T O G E T H E R SYNERGY Stent System Promus PREMIER Stent System TAXUS Element and PROMUS Element Stent Systems TAXUS Libert Stent System TAXUS Express2 Stent System PROMUS Stent System 2003 2005 2006 2009-2010 2013 2013 IC-215308-AG OCT2015 2 of 84 This material is not for use in the , France or Japan. Because you never know when life will become complex. The SYNERGY Stent System is uniquely suited for challenging cases. DESIGNED TO HEAL UNMATCHED ACUTE PERFORMANCE This material is not for use in the , France or Japan. IC-215308-AG OCT2015 3 of 84 Vascular Response to Current Permanent Polymers The case for bioabsorbable polymer coatings CoCr EES EES implanted within PES (6 months antemortem) CoCr EES Foamy macrophage accumulation (neoatherosclerosis) CoNi ZES Chronic inflammation with giant cells secondary to polymer delamination (3 months) CoCr EES Focal inflammation with eosinophils (4 months) Focal Inflammation Chronic Inflammation Neo- Atherosclerosis Late Stent Thrombosis Images Courtesy of Renu Virmani, MD.

IN-SERVICE PRESENTATION This material is not for use in the U.S., France or Japan. IC-215308-AG OCT2015 1 of 84

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