Transcription of In Vitro Models for Studying Angiogenesis - …
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In Vitro Models for Studying Angiogenesis - …
In VitroModels for Studying AngiogenesisSuparna SanyalMay 12, 2010 Overview Angiogenesis Important considerations for Studying Angiogenesis in Vitro BD in Vitro Angiogenesis Models EC tube formation EC migration EC invasionAngiogenesis Angiogenesis formation of new blood vessels (sprouting, branching etc.) from existing vessels ( wound healing, fertility etc.) Vasculogenesis formation of new blood vessels from angioblasts or progenitor stem cells ( de novovessel synthesis)ExcessiveInsufficientANGIOGENE SISC ancerRheumatoid ArthritisBlindness (Diabetic Retinopathy)PsoriasisAids ComplicationsStrokeHeart DiseaseUlcersSclerodermaInfertilityDisea ses Associated With AngiogenesisTumor AngiogenesisLocalized solid tumor Necessary for tumor growth and metastasis Inhibition of Angiogenesis represents a critical point of intervention for cancer treatment Circumvents problems of cellular toxicity and tolerance development seen with chemotherapyTumor AngiogenesisAngiogenesis Research Basic research to elucidate molecular mechanisms of Angiogenesis .
Overview • Angiogenesis • Important considerations for studying angiogenesis in vitro • BD in vitro angiogenesis models – EC tube formation – EC migration – EC invasion
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