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Information for Clinicians

Date of Issue: Author: Drs CJC Knechtli & JN Crowe Review Date: Approved by: Last Updeted: Royal United Hospital Bath NHS Trust Page 1 of 6 Guidelines for the Investigation & Management of vitamin B12 deficiency Background We frequently get asked for advice on the cause of a patient s vitamin B12 (cobalamin) deficiency and its management. For the patients with a very low serum B12 level (<100ng/l) and anaemia, macrocytosis or neurological symptoms, the treatment is simple: load the patient with vitamin B12 parenterally (by IM injection) and continue with maintenance vitamin B12 by IM injection every 3 months indefinitely (see below for more details).

Date of Issue: Author: Drs CJC Knechtli & JN Crowe Review Date: Approved by: Last Updeted: © Royal United Hospital Bath NHS Trust

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