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INFUSION REACTION PROPHYLAXIS - …

PREINFUSION MEDICATIONSCLASSDRUG(S)DOSINGTIMING IN RELATIONTO INFUSIONAnti gout flare agentColcrys (colchicine)Oral NSAIDsAdvil , Aleve CorticosteroidsPrednisone,prednisoloneIN FUSION REACTION PROPHYLAXISGOUT FLARE PROPHYLAXIS Individual physician orders may all patients taking KRYSTEXXA experience an initial drop in serum uric acid, it is recommended to take steps to proactively manage gout Please see Important Safety Information on following page and click forFull Prescribing Information, including Boxed drop in uric acid causes mobilization of uric acid crystals from stores in the body. Gout flares can be a sign that KRYSTEXXA is working to lower the uric acid in the *To be given to the patient by nurse on day of INFUSION . INFUSION reactions may occur despite pretreatment. NSAIDs=nonsteroidal anti-inflammatory drugs. Patients may still experience flares despite flare MEDICATIONS1 CLASSDRUG(S)DOSINGTIMING IN RELATIONTO INFUSION IV corticosteroids* Methylprednisolone, hydrocortisone, Other:_____Prior to each INFUSION Antihistamines* Allegra (fexofenadine), Claritin (loratadine), Benadryl (diphenhydramine)Dose determined by healthcare providerNight before INFUSION , and/or can administer concomitantly with INFUSION Oral analgesic* Tylenol (acetaminophen)Prior to each infusionDose determined by healthcare provider Patient may take any one of these drugs, as indicatedDaily, treatm

Please see Important Safety Information on following page and click for Prescribing Information, including Boxed Warning, and Medication Guide.

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