Transcription of Int J Pharm Sci Nanotech Vol 8; Issue 2 International ...
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Int J Pharm Sci Nanotech Vol 8; Issue 2 International ...
2828 Int J Pharm Sci Nanotech Vol 8; Issue 2 April June 2015 research Paper Simultaneous Determination of Dextromethorphan and Pro-methazine in pharmaceutical Syrups by Rapid HPLC Method SalehTrefi Department of Quality Control and pharmaceutical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syrian Arab Republic. Received November 11, 2014; accepted January 3, 2015 ABSTRACT A simple, precise and accurate method is validated for the simultaneous determination of two nitrogenous compounds dextromethorphan hydrobromide and promethazine hydro-chloride, which are commonly used as active ingredients in pharmaceutical syrups. The chromatographic conditions comprised of a classical C8-type stationary phase (250 mm, 5 m) with a mobile phase consisting of 3 g of sodium lauryl sulfatein a mixture of 400 ml of water and 600 ml of acetonitrile along with g of ammonium nitrate as additional agent.
2828 Int J Pharm Sci Nanotech Vol 8; Issue 2 April June 2015 Research Paper Simultaneous Determination of Dextromethorphan and Pro-methazine in Pharmaceutical Syrups by Rapid HPLC Method SalehTrefi Department of Quality Control and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Aleppo,
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