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Interactions Between Sedatives/ hypnotics / anxiolytics and Antiretrovirals antiretroviral Pharmacokinetic Characteristics (summary): Protease Inhibitors (PIs) Non-Nucleoside Reverse Transcriptase Integrase Inhibitors Inhibitors (NNRTIs). atazanavir (Reyataz )1, darunavir efavirenz (Sustiva )10, etravirine dolutegravir (Tivicay ),14, elvitegravir/cobicistat (Prezista )2, fosamprenavir (Telzir )3, (Intelence )11, nevirapine (Viramune )12, (Stribild , single-tablet regimen with indinavir (Crixivan )4, lopinavir/ritonavir rilpivirine (Edurant )13 tenofovir/emtricitabine)15, raltegravir (Kaletra )5, nelfinavir (Viracept )6, ritonavir (Isentress )16. (Norvir )7, saquinavir (Invirase )8, tipranavir (Aptivus )9. Metabolism Mainly CYP3A4 Efavirenz, nevirapine: CYP3A4, 2B6 Dolutegravir: UGT1A1, CYP3A4 (10-15%). (minor). Elvitegravir: CYP3A, UGT1A1/3.
Interactions Between Sedatives/Hypnotics/Anxiolytics and Antiretrovirals Prepared by: Michelle Foisy, Pharm.D., Northern Alberta Program, Edmonton, Alberta.
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