INTERACTIONS BETWEEN ANTIHYPERTENSIVE …

IntroductionThe vast majority of hypertensive patients is treatedwith ANTIHYPERTENSIVE drugs for many years. Othertherapeutic agents are frequently used simultaneously,thus giving rise to the possibility of drug-drug interac-tions. The potential for drug-drug INTERACTIONS increas-es with rising age, since elderly patients receive largernumber of drugs, but also because the renal excretionof several therapeutic agents is impaired in the elderly,as a result of diminishing kidney function (1, 2). Theinteractions BETWEEN ANTIHYPERTENSIVE drugs and othertherapeutic agents will be discussed and summarizedin the present issue, after a brief general explanationof the various mechanisms underlying drug-drug inter-actions. The combination and mutual interactionsbetween various categories of ANTIHYPERTENSIVE agentswill be dealt with by us in a separate issue of thisnewsletter. MechanismsThere are several mechanisms by which drugs mayinteract (3-5), and most of these mechanisms can becategorized as pharmacokinetic (involving intestinalabsorption, distribution, metabolism, and elimination)or as pharmacodynamic, or as additive toxicity, INTERACTIONS : the interaction in intes-tinal absorptionis best illustrated by an example: tetra-cylines and other broad-spectrum antibiotics mayimpair the absorption of oral contraceptives (in particu-lar those with low-dose progestogens and/or estro-gens) and hence render contraception unsafe.

Introduction The vast majority of hypertensive patients is treated with antihypertensive drugs for many years. Other therapeutic agents are frequently used simultaneously,

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