Transcription of International Normalized Ratio (INR)
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International Normalized Ratio (INR)
The Relationship of the International Normalized Ratio (INR) to the Prothrombin Time (PT) By: William DePond MD, President and Chief Medical Officer MEDLAB In 1983, it was determined that patients receiving long-term anticoagulant therapy may be subject to unnecessary risks of bleeding or thromboembolism because of variability in the commercial thromboplastins used to determine prothrombin time (PT) and consequent uncertainty about the actual intensity of anticoagulation. The accuracy of the PT was noted to be system-dependent showing variations in results due to marked variability in the response of commercial thromboplastin reagents to clotting factors (II, VII, X). This led to the introduction of the International Normalized Ratio (INR), a method developed to normalize the clotting time value by correcting for differences in reagent responsiveness.
Cytochrome P450 2C9 and VKORC1 Mutation Analysis Clinical Significance: Warfarin (coumadin) therapy is associated with significant complications because of its narrow therapeutic index and large interpatient dosage variation necessary to achieve an optimal therapeutic
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