Introduction BIOINFORMATICS - Gerstein Lab

1(c) Mark Gerstein , 1999, Yale, Gerstein , Yale (c) Mark Gerstein , 1999, Yale, +3(c) Mark Gerstein , 1999, Yale, isBioinformatics? (Molecular)Bio-informatics One idea for a definition? BIOINFORMATICS is conceptualizingbiology in terms ofmolecules(in the sense of physical-chemistry) andthen applying informatics techniques(derivedfrom disciplines such as applied math, CS, andstatistics) to understand andorganize theinformation associatedwith these molecules,on alarge-scale. BIOINFORMATICS is MIS for Molecular BiologyInformation4(c) Mark Gerstein , 1999, Yale, Biology: an Information Science Central Dogmaof Molecular BiologyDNA-> RNA-> Protein-> Phenotype-> DNA Molecules Sequence, Structure, Function Processes Mechanism, Specificity, Regulation Central Paradigmfor BioinformaticsGenomic Sequence Information-> mRNA (level)-> Protein Sequence-> Protein Structure-> Protein Function-> Phenotype Large Amounts of Information Standardized Statistical(idea from D Brutlag, Stanford, graphics from S Strobel) Genetic material Information tr

Array Data (courtesy of J Hager) Yeast Expression Data in Academia: levels for all 6000 genes! Can only sequence genome once but can do an infinite variety of these array experiments at 10 time points, 6000 x 10 = 60K floats telling signal from background

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